• Skin Care
  • Hair Care
  • Color Cosmetics
  • Body Care
  • Active Ingredients
  • Sustainability

Alpha Glucosyl Hesperidin

Circulate Vitality, Deliver Radiance―an upcycled citrus polyphenol that enhances microcirculation, defends against glycation, and helps reveal glowing, even skin.

■ Brightens dull skin and dark circles ■ Refines and smooths pores ■ Helps prevent hair thinning

Circulation

Traditionally proven benefits from citrus fruits

Alpha Glucosyl Hesperidin (AGH) is an upcycled, glycosylated derivative of hesperidin―a citrus polyphenol long valued in Asia for its ability to promote healthy blood circulation. In Japan, citrus peels have traditionally been added to hot bathwater to induce a warming sensation after bathing, an effect attributed to hesperidin.

Our proprietary glycosylation technology enhances the water solubility of hesperidin, enabling it to be effectively used in skin care products.

Scientific studies confirm that AGH stimulates blood circulation similarly to hesperidin.

Methods: 0.5% AGH cream or placebo was applied on the lips. Scanning images of the lips were taken using a laser doppler blood flowmetry.

Glowing skin

Brightens dull skin and reduce dark eye circles

Poor circulation is known to be one of the causes of skin dullness and dark eye circles. Our clinical study shows the potential of AGH as an active ingredient to address these concerns and promote a more glowing skin.

Our technical article including detailed data, titled ”Upcycled citrus polyphenol for beauty from within”, will be featured in a cosmetic science media, PERSONAL CARE MAGAZINE (October 2025 issue).

Anti-glycation

Protects against glycation-related skin damage

Skin glycation is a natural reaction that occurs within the skin when sugars bind to proteins. It is one of the fundamental causes of intrinsic skin aging, contributing to visible signs such as skin dullness and dark circles. In a study using BSA (bovine serum albumin), AGH reduced the production of carboxymethillysine and pentosidine, representative markers of glycated proteins. These results highlight the anti-glycation properties of AGH and its potential to protect skin from glycation-related damage.

Methods: BSA was incubated with glucose and AGH, and the relative amounts of carboxymethyllysine and pentosidine were measured by immunofluorescence staining.

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