AA2G^™

AA2G™ (INCI: Ascorbyl Glucoside) is a highly stable vitamin C derivative, first industrialized globally by Nagase Viita. By combining vitamin C with glucose, AA2G™ significantly enhances stability. While maintaining high stability within formulations, the skin enzymes cleave ascorbyl glucoside into vitamin C and glucose, enabling cells to uptake vitamin C upon application.

Bioavailability of ascorbyl glucoside

Intracelluler vitamin C uptake

The intracelluler vitamin C level can be maintained for a longer period compared to the vitamin C treatment, since ascorbyl glucoside gradually releases vitamin C and is taken up by cells.

Methods: NHDF (Normal Human Dermal Fibroblasts) were incubated in the media with 1 mmol/L vitamin C or ascorbyl glucoside for 8 days. Each intracellular vitamin C level was measured on day 0, 1, 2, 5 and 8.

Through the continuous release of vitamin C, AA2G^TM delivers the benefits of vitamin C to the skin. The multiple bioactive functions for brightening, anti-aging and sun care... has been scientifically proven by Nagase Viita.

Learn more about the efficacy for sun care in the technical article of “Skin friendly solution for ‘sunxiety’” which was featured in a cosmetic science media, PERSONAL CARE MAGAZINE 2025 April issue.

We are dedicated to helping our customers formulate AA2G^TM into a wide range of products by leveraging our extensive solutions and expertise in formulation development.

Example: Method for neutralizing AA2G^TM with less discoloration
By trying various kinds of neutralizers and buffers we found a method that reduces discoloration.