Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts Jun MutoEhime University Graduate School of Medicine, Department of Dermatology
Information
- Date
- Thursday, Novermber 2, 2023 Main symposium: 12:55 - 17:25 *Check-in starts at 12:30. Evening Session: 17:40 - 19:30
- Venue
Sola City Conference Center ■ Main symposium: 2F, sola city Hall ■ Evening session: 1F, Room C 4 Chome−6, Kanda Surugadai, Chiyoda City, Tokyo 101-0062 TEL: 03-6206-4855 Visiting sola city: JR Chuō Line, Sōbu Line: Ochanomizu Station 1min. Walk from Hijiribashi Exit TokyoMetro Chiyoda Line: Shin-Ochanomizu Station 0min. Walk from B2 Exit [Direct link to concourse] Toknomizu Station 4min. Walk from 1 Exit Toei Shinjuku Line: Ogawamachi Station 6min. Walk from B3 Exit *Please use public transportation as no parking is available. *The admission is on a first-come, first-served basis.
- Symposium
Associates - Sponsor: Hayashibara Co., Ltd. Supporter: The Japanese Society of Applied Glycoscience
- Capacity
- Main Symposium: 300 participants, Evening Session: 50 participants *The evening session is for the main symposium participants only.
- Admission
- Free admission for both the main symposium and evening session. (pre-registration required) *The evening session is for the main symposium participants only.
- Conference Theme
- Trehalose Leading a Sustainable Future
- Chairperson
- Masayoshi Onitsuka, Tokushima University, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Scial Sciences, Associate ProfessorTakahiro Kikawada, Institute of Agrobiological Sciences (National Agriculture and Food Research Organization (NARO), Group Leader)
Program
Trehalose Leading a Sustainable Future
Program Summary
Main Symposium
<Simultaneous English interpretation is available for the Japanese presentations.>
Time Schedule | Contents |
|---|---|
13：00 -13：10 | Opening remarks: Naoki Yasuba (Hayashibara Co., Ltd., Representative Director) |
13：10 -14：40 | SESSION 1 Chairperson: Masayoshi Onitsuka, Tokushima University, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Associate Professor I Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts Jun Muto (Department of Dermatology, Ehime University Graduate School of Medicine, Senior Assistant professor) II Formulation design and evaluation of cell preservation solution, Cellstor, containing trehalose Yasutaka Fujita, Masuhiro Nishimura, Tamaki Wada, Natsuki Komori, Chikage Shirakawa, Taichi Takenawa (Otsuka Pharmaceutical Factory, Inc.) III Hair repair effect by combination of trehalose and multifunctional moisturizing agent "isoprene glycol" Takanori Arai (Chemicals R&D Dept., Kuraray Co., Ltd.) |
14：40 -14：55 | Break |
14：55 -16：25 | SESSION 2 Chairperson: Takahiro Kikawada, Institute of Agrobiological Sciences (National Agriculture and Food Research Organization (NARO), Group Leader) IV Trehalose-based seed coatings to boost agriculture in marginal lands Benedetto Marelli (Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Associate Professor) V Chemistry and biology of trehalose-based natural products from actinomycete Yasuhiro Igarashi (Biotechnology Research Center, Toyama Prefectural University, Professor) VI Development of trehalose for feed application: Contribution to sustainability Kazuhisa Mukai (New Business Development Unit, Food System Solutions Division, Hayashibara Co., Ltd.) |
16：25 -16：35 | Break |
16：35 -17：15 | General discussion |
17：15 | Closing remarks Yoshihiko Amano (Faculty of Engineering, Shinshu University, / The Japanese Society of Applied Glycoscience, Chairman) |
The contents of the program is subject to change. Please do not take photos or screenshots of the presentation slides.
Evening Session
17：40 - 19：30 (Dinner served in a standing buffet style)
Time Schedule | Contents |
|---|---|
18：10 -18：40 | Poster Presentation Core Time/Discussion |
This is a networking event to discuss the content of the main symposium using posters.
The evening session is for the main symposium participants only.
The contents of the program is subject to change. Please do not take photos of the presentation posters.
Abstract
Ⅰ Ⅱ Formulation design and evaluation of cell preservation solution, Cellstor, containing trehaloseYasutaka Fujita, Masuhiro Nishimura, Tamaki Wada, Natsuki Komori, Chikage Shirakawa, Taichi TakenawaOtsuka Pharmaceutical Factory, Inc.
Ⅲ Hair repair effect by combination of trehalose and multifunctional moisturizing agent “isoprene glycol”Takanori AraiKuraray Co., Ltd.
Ⅳ Trehalose-based seed coatings to boost agriculture in marginal landsBenedetto MarelliMassachusetts Institute of Technology, Department of Civil and Environmental Engineering
Ⅴ Chemistry and biology of trehalose-based natural products from actinomycetesYasuhiro IgarashiToyama Prefectural University, Biotechnology Research Center
Ⅵ Development of trehalose for feed application: Contribution to sustainabilityKazuhisa MukaiHayashibara Co., Ltd., Food System Solutions Division, New Business Development Unit
Speakers
Department of Dermatology, Ehime University Graduate School of Medicine Jun Muto Biography
1993-1999 M.D., Keio University School of Medicine, Tokyo, Japan 1999 Resident, Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan 2004-2007 Assistant professor, Department of Dermatology, National Defense Medical College, Saitama, Japan 2007 Ph.D., Keio University School of Medicine, Tokyo, Japan 2008-2012 Postdoctoral fellow, Department of Dermatology, University of California, San Diego (Prof. Richard L. Gallo\'s lab) 2013-2014 Assistant project scientist, Department of Dermatology, University of California, San Diego (Prof. Richard L. Gallo\'s lab) 2014-2018 Senior Assistant professor, Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan 2018-present Senior Assistant professor, Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
Research
Elucidation of the role of glycans in skin innate immunity Effect of highly concentrated trehalose in the skin-derived cells
Otsuka Pharmaceutical Factory, Inc. Yasutaka Fujita Biography
1996 B.S. Faculty of Pharmaceutical Sciences, Okayama University 1998 M.S. Graduate School of Pharmaceutical Sciences, Okayama University 1998-present Otsuka Pharmaceutical Factory, Inc. 2023 Doctor of Engineering, Tokushima University
Research
Research on cell preservation solution, Research on xeno-islet transplantation
Affiliation Chemicals R&D Dept., Kuraray Co., Ltd. Takanori Arai Biography
2017 Bachelor of Science, Tohoku University 2020 Master of Agriculture, The University of Tokyo 2020-present Chemicals R&D Dept., Kuraray Co., Ltd.
Research
Development of multifunctional moisturizing agent "Isoprene glycol"
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology Benedetto Marelli Biography
2005 B.Sc. Biomedical Engineering – Politecnico di Milano – Italy 2008 M.Sc. Biomedical Engineering – Politecnico di Milano – Italy 2012 PhD Materials Science – McGill University – Canada 2012-2015 Postdoctoral Associate – Tufts University 2015-2021 Assistant Professor – MIT 2021-2023 Associate Professor Without Tenure – MIT 2023–present Associate Professor With Tenure
Research
Structural proteins, polysaccharides, biomacromolecules, directed-assembly, nanomanufacturing, drug delivery, food, agriculture
Biotechnology Research Center, Toyama Prefectural University Yasuhiro Igarashi Biography
1987 Bachelor of Agricultural Chemistry, University of Tokyo 1989 Master of Agricultural Chemistry, University of Tokyo 1992 Ph.D of Agricultural Chemistry, University of Tokyo 1992 Research Fellow, Fuji Photo Film Co., Ltd. 1994 Postdoctoral fellow, Johns Hopkins University School of Medicine 1996 Assistant Professor, Toyama Prefectural University 1998 Associate Professor, Toyama Prefectural University 2009 Professor, Toyama Prefectural University
Research
Exploration of novel bioactive compounds from microorganisms and diversity of secondary metabolism
New Business Development Unit, Food System Solutions Division Hayashibara Co., Ltd. Kazuhisa Mukai Biography
1993 Bachelor of Agriculture, Okayama University 1995 Master of Agriculture, Okayama University 1995-present Hayashibara Co., Ltd. 2006 Doctor of Agriculture, Okayama University
Research
Development of trehalose for feed application
Chairperson Profile
Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University Masayoshi Onitsuka Biography
2002 Bachelor of Engineering, Soka University, Tokyo, Japan 2004 Master of Science, Nara Institute of Science and Technology, Nara, Japan 2009 Doctor of Science, Nara Institute of Science and Technology, Nara, Japan 2009 Researcher, Department of Biotechnology, Graduate School of Engineering, Osaka University 2010 Researcher, Institute of Technology and Science, Tokushima University 2014 Project Assistant Professor, Institute of Technology and Science, Tokushima University 2016 Assistant Professor, Graduate School of Technology, Industrial and Social Sciences, Tokushima University 2022-present Associate Professor, Graduate School of Technology, Industrial and Social Sciences, Tokushima University
Research
Engineering the mammalian cell platform for the production of biologics
Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO) Graduate School of Frontier Sciences, The University of Tokyo Takahiro Kikawada Biography
1992 B.Sc., Faculty of Agriculture, Iwate University 1994 M.Sc., United Graduate School of Agricultural Sciences, Iwate University 1994 Researcher, National Institute of Sericological and Entomological Sciences 2001 Chief Researcher, National Institute of Agrobiological Sciences 2009 PhD, Tokyo Institute of Technology (Doctorate by way of Dissertation) Supervisor: Prof. SAKURAI Minoru 2015-present Associate Professor, Graduate School of Frontier Sciences, The University of Tokyo 2016 Principal Scientist, Institute of Agrobiological Sciences, NARO 2019 Senior Principal Scientist, Institute of Agrobiological Sciences, NARO 2023-present Group Leader, Institute of Agrobiological Sciences, NARO; Professor, The University of Tokyo
Research
Molecular mechanisms underlying anhydrobiosis in the sleeping chironomid, Polypedilum vanderplanki Development of dry-preservation technology for animal cells and tissues
Symposium Report
Participants 122
The 25th Trehalose Symposium was met successfully.
The comprehensive panel discussion following the presentations provided a platform for presenters to exchange ideas with the attendees. It was noted that the mechanisms behind trehalose’s multifunctional properties are still to be uncovered. As foundational research progresses, these insights have the potential to lead to more targeted applied research.
An evening session, revived after a four-year hiatus, served as a dynamic platform for exchanging ideas. Participants engaged in spirited discussions about the main symposium topics, utilizing posters to facilitate the dialogue.
Closing Remarks
Yoshihiko Amano
(Faculty of Engineering, Shinshu University, Dean / The Japanese Society of Applied Glycoscience, Chairman)
First and foremost, I would like to express my heartfelt thanks to the six distinguished lecturers who presented the diverse biological functions of trehalose. I listened with great interest.
My research focuses on the bio-decomposition of cellulose, the world's largest organic substance. Mushrooms are the only organisms capable of decomposing cellulose in woody biomass. While mushrooms do not produce trehalose when their mycelium is proliferating, they produce it in abundance when they form fruit bodies. This mechanism serves various purposes, including resistance to low temperatures, but I speculate this also plays a role in supplying trehalose to the world. Trehalose produced by mushrooms is supplied to animals, including us, through food and to the microorganisms in the rhizosphere, as presented today. I want to believe that the substances an organism utilizes eventually evolve into various functions after circulating in many places.
As Professor Kikawada, who chaired the general discussion, mentioned earlier, it remains a mystery why trehalose has so many biological functions. However, its stability as a substance is extremely important. Even though cello-oligosaccharides are also highly stable as all their OH groups are in the equatorial position, cellulose barely dissolves in water and thus is rarely used by living organisms. On the other hand, trehalose is a versatile substance that is water-soluble equipped with high structural symmetry. Hayashibara’s success in mass production and affordability is a major attribute of broad applications in today’s society.
More trehalose functions are yet to be discovered, and the mechanisms behind them will become clearer in time. Meantime, networks of researchers in such studies are incredibly important. I hope our collective efforts will further illuminate the path of trehalose research. With these thoughts and aspirations, I bring this symposium to a close.
Biography
1982 Bachelor of Engineering, Shinshu University, Nagano
1984 Master of Engineering, Shinshu University, Nagan
1994 Doctor of Engineering, Shinshu University, Nagano
1995 Assistant Professor, Faculty of Engineering, Shinshu University, Nagano
2005-present Professor, Faculty of Engineering, Shinshu University, Nagano
2018-present Dean, Faculty of Engineering, Shinshu University, Nagano
2023-present Chairman, The Japanese Society of Applied Glycoscience
Research
Study on biomass degrading enzymes from white-rot basidiomycetes